The good absorption of ofloxacin after oral administration is not influenced by renal. Ofloxacin is known to be excreted into breast milk after systemic administration. Logarithmicphase cultures were exposed to the peak concentrations of levofloxacin or ciprofloxacin observed in human serum after 500 mg and 750 mg oral doses, human elimination pharmacokinetics were simulated, and viable bacterial counts were measured at 0, 1, 2, 4, 6, 8, 12, 24 and 36 h. Instill 5 gtt into affected ear twice daily for 7 days. Ofloxacin floxin side effects, dosage, interactions drugs. Ofloxacin floxin side effects, dosage, interactions.
Pharmacokinetics of ofloxacin in broiler chicken, journal. Levofloxacin is significantly more active against bacterial pathogens than r. The pharmacokinetics of ofloxacin, a fluoroquinolone widely used in the treatment of bacterial infections, may be different according to age, owing to the biological differences that exist between an elderly organism and a young subject, expecially as regards the renal and the hepatic function. Absence of pharmacokinetic interaction between ofloxacin. Data on its pharmacokinetics and safety in children are limited. Pdf documents can be viewed with the free adobe reader. Pdf bioavailability and pharmacokinetics of ofloxacin in. Ofloxacin 400 mg was administered either as a 1h infusion or as an oral tablet. Reduced dosage in impaired renal or hepatic function to 100 mg 101 or 100. In addition, a large pool of data obtained in patients with a wide range of renal dysfunction is provided. Nov 28, 2016 serum, urine and tear concentrations of ofloxacin were measured in 30 healthy women at various time points during a tenday course of treatment with ofloxacin ophthalmic solution. Levaquin levofloxacin tablets levaquin levofloxacin oral. Pdf pharmacokinetics of ofloxacin after parenteral and oral. The rats were administered intravenous doses of ofloxacin 5 mg kg.
Pharmacokinetics and safety of ofloxacin in children with. The pharmacokinetics of ofloxacin in south african mdrtb patients have been elucidated, taking into account glomerular filtration and active tubular secretion as the primary elimination pathways thirtysix percent of patients failed to achieve the minimum free aucmic ratio of 100 higher doses of ofloxacin should be considered. Find patient medical information for ofloxacin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Effects of hepatic fibrosis on ofloxacin pharmacokinetics. Good bioavailability after oral administration, maximum concentration in serum within 60 min after oral administration. Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, hr 810 a new cephalosporin, ru28965 a new macrolide, and other agents against enteropathogens. Chemically, levofloxacin, a chiral fluorinated carboxyquinolone, is the pure senantiomer of the racemic drug substance ofloxacin. Between 65% and 80% of an administered oral dose of ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Twelve healthy male volunteers were investigated on four different occasions with an. Ofloxacin ophthalmic solution is unbuffered and formulated with a ph of 6. Instill 5 drops into affected ears once daily for 7 days. Serum and ultrafiltrate levels of ofloxacin were measured by means of highperformance liquid chromatography.
Ofloxacin concentrations in plasma were determined using a high. Serum, urine and tear concentrations of ofloxacin were measured in 30 healthy women at various time points during a tenday course of treatment with ocuflox solution. Twelve healthy male volunteers were investigated on four. Pharmacokinetics of ofloxacin, a fluoroquinolone antimicrobial agent, was determined in broiler chickens after intravenous or oral administration of a single dose 10 mgkg. To study the pharmacokinetics of ofloxacin using salivary drug concentration when administered alone or in combination with rifampicin r, isoniazid h and pyrazinamide z and also to assess the saliva to plasma concentration ratio. Floxin ofloxacin tablets tablets is a synthetic broadspectrum antimicrobial agent for oral administration. The mean serum ofloxacin concentration ranged from 0. Ofloxacin pharmacokinetics in saliva tspace repository. Concentrations in plasma and dialysate were measured by hplc. Levaquin levofloxacin tablets levaquin levofloxacin. The metabolic reactions of ofloxacin occur through a demethylation of 4methylpiperazine side chain and an noxidation of 4methylpiperazine side chain at the cyp site. Bioavailability and pharmacokinetics of ofloxacin in healthy volunteers article pdf available in antimicrobial agents and chemotherapy 352. Pdf pharmacokinetics of ofloxacin in serum and vitreous.
Treatment of uncomplicated gonorrhea with a single dose 400 mg p. Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases. Singledose pharmacokinetics of ofloxacin during continuous. Ofloxacin is a broadspectrum, synthetic fluoroquinolone antibacterial agent for oral administration. An invitro pharmacokinetic model was used to compare the pharmacodynamics of levofloxacin and ciprofloxacin against four penicillinsusceptible and four penicillinresistant streptococcus pneumoniae. Pharmacokinetics of ofloxacin and adequacy of maintenance. The pharmacokinetics and bioavailability of ofloxacin in 20 healthy male volunteers were studied in an openlabel, randomized, twoway crossover study. Pdf pharmacokinetics of ofloxacin after parenteral and.
Following oral administration, the bioavailability of ofloxacin in the tablet formulation is approximately 98%. Levaquin levofloxacin is a synthetic broad spectrum antibacterial agent for oral and intravenous administration. It would be best to get this clarified while placing the order. The pharmacokinetics of ofloxacin were studied at the end of the treatment period before, during and after a haemodialysis session. Deen dayal upadhyaya veterinary science university, mathura281 001, india. Pharmacokinetic data on ofloxacin in critically ill patients on renal replacement therapy are sparse and conflicting. Dose related pharmacokinetics of ofloxacin in healthy volunteers article pdf available in the international journal of tuberculosis and lung disease 611. Ofloxacin stops the multiplication of bacteria by inhibiting the reproduction and repair of their genetic material dna. Pharmacokinetics of ofloxacin in elderly patients and in.
The good absorption of ofloxacin after oral administration is not. The pharmacodynamic properties of levofloxacin an optically active isomer of ofloxacin, ofloxacin, and ciprofloxacin, alone and in combination with rifampin, were evaluated over 24 to 48 h against clinical isolates of methicillinsusceptible and resistant staphylococcus aureus mssa 1199 and mrsa 494, respectively in an in vitro infection model. The clinical pharmacokinetics of levofloxacin springerlink. Pharmacokinetics of ofloxacin after parenteral and oral. The chemical name is s9fluoro2,3dihydro3methyl104methyl. Maximum serum concentrations are achieved one to two hours after an oral dose. Eight patients with anuric acute renal failure were administered 400 mg of ofloxacin intravenously. Ofloxacin did not significantly influence the pharmacokinetics of napa, nor.
Find patient medical information for ofloxacin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The possible pharmacokinetic interaction between a new quinolone and fenbufen was investigated by comparing the plasma concentration. Plasma concentration profiles were analyzed by the. Pharmacokinetics of ofloxacin in serum and vitreous humor of albino and pigmented rabbits article pdf available in antimicrobial agents and chemotherapy 397. Instill 10 drops into affected ears once daily for 7 days.
Ten lactating women time postpartum not stated were given ofloxacin 400 mg orally every 12 hours for 3 doses. Subject demographic characteristics groupa ageyrb no. The possible roles of small intestinal pglycoprotein pgp and cytochrome p450 cyp in the bioavailability of ofloxacin were also evaluated. Effects of hepatic fibrosis on ofloxacin pharmacokinetics in. Chronic suppurative otitis media with perforated tympanic membranes. Ofloxacin is a fluoroquinolone antibiotic that is excreted in the urine as unchanged drug via active tubular secretion and glomerular filtration. Pharmacodynamics of levofloxacin and ciprofloxacin against. Bioavailability and pharmacokinetics of ofloxacin in healthy. The mean area under the concentrationtime curve auc and peak plasma concentration c max. The pharmacokinetics of ofloxacin, a fluoroquinolone widely used in the treatment of bacterial infections, may be different according to age, owing to the biological differences that exist between an elderly organism and a young subject, expecially as. Ofloxacin pharmacokinetics in chronic renal failure and. Application site reaction 117% taste perversion 7% paresthesia 1% transient hearing loss. Plasma concentration profiles were analyzed by the noncompartmental method.
The pharmacokinetics of ofloxacin, desmethyl ofloxacin and ofloxacin noxide in haemodialysis patients with endstage renal disease. Pharmacokinetics of ofloxacin after a single intravenous bolus dose in neonatal calves. However, the reports on the pharmacokinetics of ofloxacin in cld were less well known or conflicting. Serum, urine and tear concentrations of ofloxacin were measured in 30 healthy women at various time points during a tenday course of treatment with ofloxacin ophthalmic solution. Its commonly used as an eye drop to treat conjunctivitis pink eye and corneal ulcers the tablet form of ofloxacin is. It belongs to the fluoroquinolone class of antibiotics which includes levofloxacin, ciprofloxacin, gatifloxacin, norfloxacin, moxifloxacin, trovafloxacin and others. A patients guide to clinical trials maintitle a doubleblind study to evaluate the safety and pharmacokinetics of l ofloxacin rwj 252 in subjects with hiv infection. The bioavailability of ofloxacin in the tablet form is roughly 98% following oral administration, reaching maximum serum concentrations within one to two hours.
Ofloxacin is thought to exert a bactericidal effect on susceptible bacterial cells by inhibiting the essential bacterial enzyme dna gyrase, a critical catalyst in the duplication, transcription and repair of bacteria. Ofloxacin ophthalmic solution ofloxacin ophthalmic. Logarithmicphase cultures were exposed to the peak concentrations of levofloxacin or ciprofloxacin observed in human serum after 500 mg. Bioavailability and pharmacokinetics of ofloxacin in. Ofloxacin is a quinolone administered to patients with severe infections.
Levofloxacin is a fluoroquinolone antibiotic and is the optical s. Pharmacokinetics of ofloxacin in broiler chicken, journal of. Ofloxacin is widely used for the treatment of multidrugresistant tuberculosis mdrtb. Rapidly and almost completely absorbed from gi tract. Pharmacokinetics of ofloxacin after parenteral and oral administration article pdf available in antimicrobial agents and chemotherapy 319.
Jun 01, 2006 pharmacokinetics of ofloxacin, a fluoroquinolone antimicrobial agent, was determined in broiler chickens after intravenous or oral administration of a single dose 10 mgkg. Oct 25, 2012 levofloxacin is a fluoroquinolone antibiotic and is the optical s. The purpose of the present work was to study the pharmacokinetics of ofloxacin, a poorly metabolised drug, in experimental hepatic fibrosis. Ofloxacin ophthalmic solution ofloxacin ophthalmic solution. Ofloxacin pharmacokinetics absorption bioavailability. It has a broad spectrum of in vitro activity against grampositive and gramnegative bacteria, as well as certain other pathogens such as mycoplasma, chlamydia, legionella and mycobacteria spp. Ofloxacin is an antibiotic that is used to treat bacterial infections.
Instill 10 gtt twice daily for 14 days in affected ear s adverse effects. Pharmacokinetics of single intravenous bolus dose of. To test the hypothesis that ofloxacin may interfere with the renal elimination of procainamide, 9 healthy volunteers were randomly assigned to receive 1 g of oral procainamide as a single dose with or. Ofloxacin is a fluorinated 4quinolone which differs from other fluorinated 4quinolones in that there is a six member pyridobenzoxazine ring from positions 1 to 8 of the basic ring structure.
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